Paediatric Respiratory Reviews
Volume 11, Issue 1 , Pages 46-53 , March 2010

The Role of Heliox in Paediatric Respiratory Disease

  • Marie D. Frazier

      Affiliations

    • Division of Critical Care, Marshall University, Huntington, WV 25701, USA
    • Corresponding Author InformationCorresponding authors. Tel.: +1 304 691 1300; Fax: +1 304 691 1375.
  • ,
  • Ira M. Cheifetz

      Affiliations

    • Paediatric Critical Care Medicine, Paediatric Intensive Care Unit, Duke Children's Hospital, Durham, NC 277710, USA
    • Corresponding Author InformationCorresponding authors. Tel.: +1 304 691 1300; Fax: +1 304 691 1375.

References 

  1. Barach AL. Use of Helium as a new therapeutic gas. Soc Exp Biol Med. 1934;32:462–464
  2. Kass JE, Terregino CA. The effect of heliox in acute severe asthma: a randomized controlled trial. Chest. 1999 Aug;116:296–300
  3. Duncan PG. Efficacy of helium--oxygen mixtures in the management of severe viral and post-intubation croup. Can Anaesth Soc J. 1979 May;26:206–212
  4. Hollman G, Shen G, Zeng L, Yngsdal-Krenz R, Perloff W, Zimmerman J, et al. Helium-oxygen improves Clinical Asthma Scores in children with acute bronchiolitis. Crit Care Med. 1998 Oct;26:1731–1736
  5. Martinon-Torres F, Rodriguez-Nunez A, Martinon-Sanchez JM. Heliox therapy in infants with acute bronchiolitis. Paediatrics. 2002 Jan;109:68–73
  6. Jolliet P, Tassaux D, Thouret JM, Chevrolet JC. Beneficial effects of helium:oxygen versus air:oxygen noninvasive pressure support in patients with decompensated chronic obstructive pulmonary disease. Crit Care Med. 1999 Nov;27:2422–2429
  7. Homer L, Kayar S. Density, Heat Capacity, Viscosity, and Thermal Conductivity of Mixtures of CO2, HE, H2, H2O, N2, and O2. Bethesda, MD: Naval Medical Research Institute; 1994;
  8. Rodeberg DA, Easter AJ, Washam MA, Housinger TA, Greenhalgh DG, Warden GD. Use of a helium-oxygen mixture in the treatment of postextubation stridor in paediatric patients with burns. J Burn Care Rehabil. 1995 Sep-Oct;16:476–480
  9. Brown L, Sherwin T, Perez JE, Perez DU. Heliox as a temporizing measure for paediatric foreign body aspiration. Acad Emerg Med. 2002 Apr;9:346–347
  10. Custer JR. A randomized trial of a single dose of oral dexamethasone for mild croup. J Pediatr. 2005 Mar;146:434–435
  11. Geelhoed GC, Macdonald WB. Oral and inhaled steroids in croup: a randomized, placebo-controlled trial. Pediatr Pulmonol. 1995 Dec;20:355–361
  12. Milner AD. The role of corticosteroids in bronchiolitis and croup. Thorax. 1997 Jul;52:595–597
  13. Kairys SW, Olmstead EM, O’Connor GT. Steroid treatment of laryngotracheitis: a meta-analysis of the evidence from randomized trials. Paediatrics. 1989 May;83:683–693
  14. Fitzgerald D, Mellis C, Johnson M, Allen H, Cooper P, Van Asperen P. Nebulized budesonide is as effective as nebulized adrenaline in moderately severe croup. Paediatrics. 1996 May;97:722–725
  15. Grosz AH, Jacobs IN, Cho C, Schears GJ. Use of helium-oxygen mixtures to relieve upper airway obstruction in a paediatric population. Laryngoscope. 2001 Sep;111:1512–1514
  16. Terregino CA, Nairn SJ, Chansky ME, Kass JE. The effect of heliox on croup: a pilot study. Acad Emerg Med. 1998 Nov;5:1130–1133
  17. Weber JE, Chudnofsky CR, Younger JG, Larkin GL, Boczar M, Wilkerson MD, et al. A randomized comparison of helium-oxygen mixture (Heliox) and racemic epinephrine for the treatment of moderate to severe croup. Paediatrics. 2001 Jun;107:E96
  18. Pelletier AJ, Mansbach JM, Camargo CA. Direct medical costs of bronchiolitis hospitalizations in the United States. Paediatrics. 2006 Dec;118:2418–2423
  19. Wang E, Law B, Stephens D. Paediatric Investigators Collaborative Network on Infections in Canada (PICNIC) prospective study of risk factors and outcomes in patients hospitalized with respiratory syncytial viral lower respiratory tract infection. J Pediatr. 1995;126:212–219
  20. Thia LP, McKenzie SA, Blyth TP, Minasian CC, Kozlowska WJ, Carr SB. Randomised controlled trial of nasal continuous positive airways pressure (CPAP) in bronchiolitis. Arch Dis Child. 2008 Jan;93:45–47
  21. Patel H, Platt R, Lozano JM, Wang EE. Glucocorticoids for acute viral bronchiolitis in infants and young children. Cochrane Database Syst Rev. 2004:CD004878.
  22. Liet JM, Millotte B, Tucci M, Laflammme S, Hutchison J, Creery D, et al. Noninvasive therapy with helium-oxygen for severe bronchiolitis. J Pediatr. 2005 Dec;147:812–817
  23. Cambonie G, Milesi C, Fournier-Favre S, Counil F, Jaber S, Picaud JC, et al. Clinical effects of heliox administration for acute bronchiolitis in young infants. Chest. 2006 Mar;129:676–682
  24. Gross MF, Spear RM, Peterson BM. Helium-oxygen mixture does not improve gas exchange in mechanically ventilated children with bronchiolitis. Crit Care. 2000;4:188–192
  25. Gross M, Spear R. Helium-oxygen mixture decreases intrapulmonary shunting in mechanically ventilated children with bronchiolitis. Crit Care Med. 1999 Jan;27:163A
  26. National Asthma Education and Prevention Program (National Heart Lung and Blood Institute): Guidelines for the Diagnosis and Management of Asthma: Expert Panel Report 3. Bethesda, MD, US Department of Health and Human Services, National Institutes of Health, National Heart Lung and Blood Institute. 2007.
  27. Kudukis TM, Manthous CA, Schmidt GA, Hall JB, Wylam ME. Inhaled helium-oxygen revisited: effect of inhaled helium-oxygen during the treatment of status asthmaticus in children. J Pediatr. 1997 Feb;130:217–224
  28. Carter ER, Webb CR, Moffitt DR. Evaluation of heliox in children hospitalized with acute severe asthma. A randomized crossover trial. Chest. 1996 May;109:1256–1261
  29. Manthous CA, Hall JB, Caputo MA, Walter J, Klocksieben JM, Schmidt GA, et al. Heliox improves pulsus paradoxus and peak expiratory flow in nonintubated patients with severe asthma. Am J Respir Crit Care Med. 1995 Feb;151(2 Pt 1):310–314
  30. Abd-Allah SA, Rogers MS, Terry M, Gross M, Perkin RM. Helium-oxygen therapy for paediatric acute severe asthma requiring mechanical ventilation. Pediatr Crit Care Med. 2003 Jul;4:353–357
  31. Schaeffer EM, Pohlman A, Morgan S, Hall JB. Oxygenation in status asthmaticus improves during ventilation with helium-oxygen. Crit Care Med. 1999 Dec;27:2666–2670
  32. Bisgaard H. Delivery of inhaled medication to children. J Asthma. 1997;34:443–467
  33. Bandi V, Velamuri S, Sirgi C, Wendt J, Wendt R, Guntupalli K. Deposition pattern of heliox-driven bronchodilator aerosol in the airways of stable asthmatics. J Asthma. 2005 Sep;42:583–586
  34. Kress JP, Noth I, Gehlbach BK, Barman N, Pohlman AS, Miller A, et al. The utility of albuterol nebulized with heliox during acute asthma exacerbations. Am J Respir Crit Care Med. 2002 May 1;165:1317–1321
  35. Piva JP, Menna Barreto SS, Zelmanovitz F, Amantea S, Cox P. Heliox versus oxygen for nebulized aerosol therapy in children with lower airway obstruction. Pediatr Crit Care Med. 2002 Jan;3:6–10
  36. Rivera ML, Kim TY, Stewart GM, Minasyan L, Brown L. Albuterol nebulized in heliox in the initial ED treatment of paediatric asthma: a blinded, randomized controlled trial. Am J Emerg Med. 2006 Jan;24:38–42
  37. Kim IK, Phrampus E, Venkataraman S, Pitetti R, Saville A, Corcoran T, et al. Helium/oxygen-driven albuterol nebulization in the treatment of children with moderate to severe asthma exacerbations: a randomized, controlled trial. Paediatrics. 2005 Nov;116:1127–1133

PII: S1526-0542(09)00076-1

doi: 10.1016/j.prrv.2009.10.008

Paediatric Respiratory Reviews
Volume 11, Issue 1 , Pages 46-53 , March 2010