Paediatric Respiratory Reviews
Volume 9, Issue 3 , Pages 160-167 , September 2008

Early Detection of Lung Disease in Children with Cystic Fibrosis Using Lung Function

  • Sarath Ranganathan

      Affiliations

    • Department of Respiratory Medicine, Royal Children's Hospital Melbourne, Australia
    • Infection, Immunity & Environment Theme, Murdoch Children's Research Institute, Melbourne, Australia
    • Department of Paediatrics, University of Melbourne, Australia
  • ,
  • Barry Linnane

      Affiliations

    • Department of Respiratory Medicine, Royal Children's Hospital Melbourne, Australia
    • Infection, Immunity & Environment Theme, Murdoch Children's Research Institute, Melbourne, Australia
  • ,
  • Gary Nolan

      Affiliations

    • Respiratory Medicine, Princess Margaret Hospital for Children, Perth, Australia
    • Clinical Sciences, Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia
  • ,
  • Catherine Gangell

      Affiliations

    • Clinical Sciences, Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia
    • School of Paediatric and Child Health, University of Western Australia, Perth, Australia
  • ,
  • Graham Hall

      Affiliations

    • Respiratory Medicine, Princess Margaret Hospital for Children, Perth, Australia
    • Clinical Sciences, Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia
    • School of Paediatric and Child Health, University of Western Australia, Perth, Australia
    • Corresponding Author InformationCorresponding author. Respiratory Medicine, Princess Margaret Hospital, GPO Box D184, Perth WA 6840, Australia. Tel.: +61 8 9340 8830; Fax: +61 8 9340 8181.

References 

  1. Brennan S, Hall GL, Horak F, et al. Correlation of forced oscillation technique in preschool children with cystic fibrosis with pulmonary inflammation. Thorax. 2005;60:159–163
  2. Balough K, McCubbin M, Weinberger M, Smits W, Ahrens R, Fick R. The relationship between infection and inflammation in the early stages of lung disease from cystic fibrosis. Pediatr Pulmonol. 1995;20:63–70
  3. Khan TZ, Wagener JS, Bost T, Martinez J, Accurso FJ, Riches DW. Early pulmonary inflammation in infants with cystic fibrosis. Am J Respir Crit Care Med. 1995;151:1075–1082
  4. Gappa M, Ranganathan SC, Stocks J. Lung function testing in infants with cystic fibrosis: lessons from the past and future directions. Pediatr Pulmonol. 2001;32:228–245
  5. Dakin CJ, Numa AH, Wang HE, Morton JR, Vertzyas CC, Henry RL. Inflammation, infection, and pulmonary function in infants and young children with cystic fibrosis. Am J Respir Crit Care Med. 2002;165:904–910
  6. Nixon GM, Armstrong DS, Carzino R, et al. Early airway infection, inflammation, and lung function in cystic fibrosis. Arch Dis Child. 2002;87:306–311
  7. Ranganathan SC, Dezateux C, Bush A, et al. Airway function in infants newly diagnosed with cystic fibrosis. Lancet. 2001;358:1964–1965
  8. Kozlowska W, Aurora P, Lum S, et al. Longitudinal assessment of lung function in infants and pre-school children with cystic fibrosis. Arch Dis Child. 2004;89(Suppl 1):A38
  9. Martinez TM, Llapur CJ, Williams TH, et al. High-resolution computed tomography imaging of airway disease in infants with cystic fibrosis. Am J Respir Crit Care Med. 2005;172:1133–1138
  10. Rosenfeld M, Gibson RL, McNamara S, et al. Early pulmonary infection, inflammation, and clinical outcomes in infants with cystic fibrosis. Pediatr Pulmonol. 2001;32:356–366
  11. Beydon N, Davis SD, Lombardi E, et al. on behalf of the American Thoracic Society/European Respiratory Society Working Group on Infant and Young Children Pulmonary Function An Official American Thoracic Society/European Respiratory Society Statement: Pulmonary Function Testing in Preschool Children. Am J Respir Crit Care Med. 2007;175:1304–1345
  12. Burns JL, Gibson RL, McNamara S, et al. Longitudinal assessment of Pseudomonas aeruginosa in young children with cystic fibrosis. J Infect Dis. 2001;183:444–452
  13. Bridge PD, Ranganathan S, McKenzie SA. Measurement of airway resistance using the interrupter technique in preschool children in the ambulatory setting. Eur Respir J. 1999;13:792–796
  14. Beydon N, Amsallem F, Bellet M, et al. Pulmonary function tests in preschool children with cystic fibrosis. Am J Respir Crit Care Med. 2002;166:1099–1104
  15. Nielsen KG, Pressler T, Klug B, Koch C, Bisgaard H. Serial lung function and responsiveness in cystic fibrosis during early childhood. Am J Respir Crit Care Med. 2004;169:1209–1216
  16. Gangell CL, Horak F, Patterson HJ, Sly PD, Stick SM, Hall GL. Respiratory impedance in children with cystic fibrosis using forced oscillations in clinic. Eur Respir J. 2007;30:892–897
  17. Marostica PJC, Weist AD, Eigen H, et al. Spirometry in 3- to 6-year-old children with cystic fibrosis. Am J Respir Crit Care Med. 2002;166:67–71
  18. Vilozni D, Bentur L, Efrati O, et al. Spirometry in early childhood in cystic fibrosis patients. Chest. 2007;131:356–361
  19. Aurora P, Bush A, Gustafsson P, et al. on behalf of the London Cystic Fibrosis Multiple-breath washout as a marker of lung disease in preschool children with cystic fibrosis. Am J Respir Crit Care Med. 2005;171:249–256
  20. ATS/ERS statement: raised volume forced expirations in infants: guidelines for current practice. Am J Respir Crit Care Med 2005; 172: 1463–1471.
  21. Hoo AF, Dezateux C, Hanrahan JP, Cole TJ, Tepper RS, Stocks J. Sex-specific prediction equations for Vmax(FRC) in infancy: a multicenter collaborative study. Am J Respir Crit Care Med. 2002;165:1084–1092
  22. Jones M, Castile R, Davis S, et al. Forced expiratory flows and volumes in infants. Normative data and lung growth. Am J Respir Crit Care Med. 2000;161:353–359
  23. Ranganathan SC, Bush A, Dezateux C, et al. Relative ability of full and partial forced expiratory maneuvers to identify diminished airway function in infants with cystic fibrosis. Am J Respir Crit Care Med. 2002;166:1350–1357
  24. Ranganathan SC, Stocks J, Dezateux C, et al. The evolution of airway function in early childhood following clinical diagnosis of cystic fibrosis. Am J Respir Crit Care Med. 2004;169:928–933
  25. Stocks J, Godfrey S, Beardsmore C, Bar-Yishay E, Castile R. Plethysmographic measurements of lung volume and airway resistance. Eur Respir J. 2001;17:302–312
  26. Morris MG, Gustafsson P, Tepper R, Gappa M, Stocks J. The bias flow nitrogen washout technique for measuring the functional residual capacity in infants. Eur Respir J. 2001;17:529–536
  27. McNaughton SA, Stormont DA, Shepherd RW, Francis PWJ, Dean B. Growth failure in cystic fibrosis. J Paediatr Child Health. 1999;35:86–92
  28. Frey U, Stocks J, Coates A, Sly P, Bates J. Specifications for equipment used for infant pulmonary function testing. ERS/ATS Task Force on Standards for Infant Respiratory Function Testing. European Respiratory Society/American Thoracic Society. Eur Respir J. 2000;16:731–740
  29. Subbarao P, Hulskamp G, Stocks J. Limitations of electronic compensation for measuring plethysmographic airway resistance in infants. Pediatr Pulmonol. 2005;40:45–52
  30. Castile RG, Iram D, McCoy KS. Gas trapping in normal infants and in infants with cystic fibrosis. Pediatr Pulmonol. 2004;37:461–469
  31. Davis SD, Brody AS, Emond MJ, Brumback LC, Rosenfeld M. Endpoints for clinical trials in young children with cystic fibrosis. Proc Am Thorac Soc. 2007;4:418–430
  32. Lum S, Gustafsson P, Ljungberg H, et al. Early detection of cystic fibrosis lung disease: multiple-breath washout versus raised volume tests. Thorax. 2007;62:341–347
  33. Gustafsson PM, de Jong PA, Tiddens HA, Lindblad A. Multiple-breath inert gas washout and spirometry vs. structural lung disease in cystic fibrosis. Thorax. 2008;63:129–134
  34. Aurora P, Kozlowska W, Stocks J. Gas mixing efficiency from birth to adulthood measured by multiple-breath washout. Respir Physiol Neurobiol. 2005;148:125–139
  35. Gustafsson PM. Peripheral airway involvement in CF and asthma compared by inert gas washout. Pediatr Pulmonol. 2007;42:168–176
  36. Chavasse RJ, Bastian-Lee Y, Seddon P. Comparison of resistance measured by the interrupter technique and by passive mechanics in sedated infants. Eur Respir J. 2001;18:330–334
  37. Hall GL, Wildhaber JH, Cernelc M, Frey U. Evaluation of the interrupter technique in healthy, unsedated infants. Eur Respir J. 2001;18:982–988
  38. Gappa M, Colin AA, Goetz I, Stocks J. Passive respiratory mechanics: the occlusion techniques. Eur Respir J. 2001;17:141–148
  39. Katier N, Uiterwaal CS, de Jong BM, Verheij TJ, van der Ent CK. Passive respiratory mechanics measured during natural sleep in healthy term neonates and infants up to 8 weeks of life. Pediatr Pulmonol. 2006;41:1058–1064
  40. Oostveen E, MacLeod D, Lorino H, et al. The forced oscillation technique in clinical practice: methodology, recommendations and future developments. Eur Respir J. 2003;22:1026–1041
  41. Frey U. Forced oscillation technique in infants and young children. Paediatr Respir Rev. 2005;6:246–254
  42. Hantos Z, Adamicza A, Govaerts E, Daroczy B. Mechanical impedances of lungs and chest wall in the cat. J Appl Physiol. 1992;73:427–433
  43. Delacourt C, Lorino H, Fuhrman C, et al. Comparison of the forced oscillation technique and the interrupter technique for assessing airway obstruction and its reversibility in children. Am J Respir Crit Care Med. 2001;164:965–972
  44. Delacourt C, Lorino H, Herve-Guillot M, Reinert P, Harf A, Housset B. Use of the forced oscillation technique to assess airway obstruction and reversibility in children. Am J Respir Crit Care Med. 2000;161:730–736
  45. Ducharme FM, Davis GM, Ducharme GR. Pediatric reference values for respiratory resistance measured by forced oscillation. Chest. 1998;113:1322–1328
  46. Hall GL, Sly PD, Fukushima T, et al. Respiratory function in healthy young children using forced oscillations. Thorax. 2007;62:521–526
  47. Klug B, Bisgaard H. Specific airway resistance, interrupter resistance, and respiratory impedance in healthy children aged 2–7 years. Pediatr Pulmonol. 1998;25:322–331
  48. Malmberg LP, Pelkonen A, Poussa T, Pohianpalo A, Haahtela T, Turpeinen M. Determinants of respiratory system input impedance and bronchodilator response in healthy Finnish preschool children. Clin Physiol Functional Imaging. 2002;22:64–71
  49. Merkus PJ, Mijnsbergen JY, Hop WC, de Jongste JC. Interrupter resistance in preschool children: measurement characteristics and reference values. Am J Respir Crit Care Med. 2001;163:1350–1355
  50. Aurora P, Stocks J, Oliver C, et al. Quality control for spirometry in preschool children with and without lung disease. Am J Respir Crit Care Med. 2004;169:1152–1159
  51. Nystad W, Samuelsen SO, Nafstad P, Edvardsen E, Stensrud T, Jaakkola JJ. Feasibility of measuring lung function in preschool children. Thorax. 2002;57:1021–1027
  52. Rosenthal M, Hodson BA, Geddes DM. Physiological monitoring of older children and adults. In: Cystic Fibrosis. London: Hodder Arnold; 2007;p. 345–352
  53. Gustafsson PM. Inert gas washout in preschool children. Paediatr Respir Rev. 2005;6:239–245
  54. Lebecque P, Stanescu D. Respiratory resistance by the forced oscillation technique in asthmatic children and cystic fibrosis patients. Eur Respir J. 1997;10:891–895
  55. Hellinckx J, De Boeck K, Demedts M. No paradoxical bronchodilator response with forced oscillation technique in children with cystic fibrosis. Chest. 1998;113:55–59
  56. Gangell C, Hall GL, Stick SM, Brennan S, Sly PD. Forced oscillation technique reflects lung disease in young children with cystic fibrosis. Eur Respir J. 2007;30:33s

PII: S1526-0542(08)00036-5

doi: 10.1016/j.prrv.2008.05.002

Paediatric Respiratory Reviews
Volume 9, Issue 3 , Pages 160-167 , September 2008