Paediatric Respiratory Reviews
Volume 7 , Pages S14-S16 , 2006

Multiple-breath washout in preschool children – FRC and ventilation inhomogeneity

  • Paul Aurora

      Affiliations

    • Portex Respiratory Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    • Cardiorespiratory and Critical Care Division, Great Ormond Street Hospital for Children, London, UK
    • Corresponding Author InformationTel.: +44 20 7905 2382; Fax: +44 20 7829 8634.

References 

  1. Wall MA. Moment analysis of multibreath nitrogen washout in young children. J Appl Physiol. 1985;59:274–279
  2. Couriel JM, Schier M, Hutchinson AA, Phelan PD, Landau LI. Distribution of ventilation in young children with cystic fibrosis. Pediatr Pulmonol. 1985;1:314–318
  3. Gustafsson PM, Aurora P, Lindblad A. Evaluation of ventilation maldistribution as an early indicator of lung disease in children with cystic fibrosis. Eur Respir J. 2003;22:972–979
  4. Aurora P, Bush A, Gustafsson P, Oliver C, Wallis C, Price J, et al. Multiple-breath washout as a marker of lung disease in preschool children with cystic fibrosis. Am J Respir Crit Care Med. 2005;179:249–256
  5. Gustafsson PM. Inert gas washout in preschool children. Paediatr Respir Rev. 2005;6:239–245
  6. The ATS/ERS working group on infant and young children pulmonary function testing. The Multiple Breath Inert Gas Washout (MBW) technique in preschool children: Recommendations. Am J Respir Crit Care Med, under review 2006.
  7. Larsson A, Jonmarker C, Werner O. Ventilation inhomogeneity during controlled ventilation. Which index should be used?. J Appl Physiol. 1988;65:2030–2039
  8. Crawford AB, Makowska M, Paiva M, Engel LA. Convection- and diffusion-dependent ventilation maldistribution in normal subjects. J Appl Physiol. 1985;59:838–846
  9. Verbanck S, Schuermans D, Van Muylem A, Melot C, Noppen M, Vincken W, et al. Conductive and acinar lung-zone contributions to ventilation inhomogeneity in COPD. Am J Respir Crit Care Med. 1998;157:1573–1577
  10. Paiva M, Engel LA. The anatomical basis for the sloping N2 plateau. Respir Physiol. 1981;44:325–337
  11. Aurora P, Kozlowska W, Stocks J. Gas mixing efficiency from birth to adulthood measured by multiple-breath washout. Respir Physiol Neurobiol. 2005;148:125–139

PII: S1526-0542(06)00050-9

doi: 10.1016/j.prrv.2006.04.019

Paediatric Respiratory Reviews
Volume 7 , Pages S14-S16 , 2006

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