Paediatric Respiratory Reviews
Volume 5, Issue 2 , Pages 155-161 , June 2004

Asthma phenotypes in childhood: lessons from an epidemiological approach

  • Renato T Stein

      Affiliations

    • Pediatric Pulmonary Section, Department of Pediatrics, Pontificia Universidade Católica RS, Porto Alegre, Brazil
    • Corresponding Author InformationCorrespondence to: R. T. Stein.
    • ,
  • Fernando D Martinez

      Affiliations

    • Arizona Respiratory Center, University of Arizona, Tucson, AZ, USA

References 

  1. Stein RT, Holberg CJ, Morgan WJ, et al.  Peak flow variability, methacholine responsiveness and atopy as markers for detecting different phenotypes in childhood. Thorax. 1997;52:946–952
  2. McKenzie S. Clinical features and their assessment. In: Silverman M (ed.). Childhood Asthma and Other Wheezing Disorders. London: Chapman & Hall Medical, 1995.
  3. Silverman M, Wilson NM. Wheezing disorders in children. In: Silverman M (ed.). Childhood Asthma and Other Wheezing Disorders. London: Chapman & Hall Medical, 1995.
  4. Oswald H, Phelan PD, Lanigan A, et al.  Childhood asthma and lung function in mid-adult life. Pediatr Pulmonol. 1997;23:14–20
  5. Kelly WJW, Hidson I, Raven J, Phelan D, Pain MCF, Olinski A. Childhood asthma and lung function. Am Rev Respir Dis. 1988;138:26–30
  6. Zeiger RS, Dawson C, Weiss S. Relationship between duration of asthma and asthma severity among children in the Childhood Asthma Management Program. J Allergy Clin Immunol. 1999;103:376–387
  7. Sears MR, Greene JM, Willan AR, et al.  A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med. 2003;349:1414–1422
  8. Jenkins MA, Hopper JL, Bowes G, Carlin JB, Flander LB, Giles GG. Factors in childhood as predictors of asthma in adult life. BMJ. 1994;309:90–93
  9. Phelan PD, Robertson CF, Olinsky A. The Melbourne asthma study: 1964–1999. J Allergy Clin Immunol. 2002;109:189–194
  10. Oswald H, Phelan PD, Lanigan A, Hibbert M, Bowers G, Olinsky A. Outcome of childhood asthma in mid-adult life. BMJ. 1994;309:95–96
  11. Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life: relation with lung function, total serum IgE levels and skin test reactivity to allergens. N Engl J Med. 1995;332:133–138
  12. Martinez FD, Morgan WJ, Wright AL, Taussig LM. Diminished lung function as a predisposing factor for wheezing respiratory illness in infants. N Engl J Med. 1988;319:1112–1117
  13. Stern DA, Morgan WJ, Taussig LM, Wright AL, Halonen M, Martinez FD. Lung function at age 11 in relation to early wheezing (abstract). Am J Respir Crit Care Med. 1999;195:A148
  14. Martinez FD. Role of respiratory infection in onset of asthma and chronic obstructive pulmonary disease. Clin Exp Allergy. 1999;29:53–58
  15. Stein RT, Holberg CJ, Morgan WJ, et al.  Peak flow variability methacholine responsiveness and atopy as markers for detecting different wheezing phenotypes in childhood. Thorax. 1997;52:946–952
  16. Hanrahan JP, Brown RW, Carey VJ, Castile RG, Speizer FE, Tager IB. Passive respiratory mechanics in healthy infants. Effects on growth, gender, and smoking. Am J Respir Crit Care Med. 1996;154:670–680
  17. Speer CP, Silverman M. Issues relating to children born prematurely. Eur Respir J. 1998;27:13S–16S
  18. Ball TM, Castro-Rodriguez JA, Griffith KA, Holberg CJ, Martinez FD, Wright AL. Siblings, day-care attendance, and the risk of asthma and wheezing during childhood. N Engl J Med. 2000;343:538–543
  19. Stein RT, Holberg CJ, Sherrill D, et al.  Influence of parental smoking on respiratory symptoms during the first decade of life: the Tucson Children’s Respiratory Study. Am J Epidemiol. 1999;149:1030–1037
  20. Soyseth V, Kongerud J, Boe J. Postnatal maternal smoking, increases the prevalence of asthma but not of bronchial hyperresponsiveness or atopy in their children. Chest. 1995;107:389–394
  21. Stein RT, Sherril D, Morgan WJ, et al.  Respiratory syncitial virus in early life and risk of wheeze and allergy by age 13 years. Lancet. 1999;354:541–545
  22. Penny ME, Murad S, Madrid SS, et al.  Respiratory symptoms, asthma, exercise test spirometry, and atopy in school children from a Lima shanty town. Thorax. 2001;56:607–612
  23. Lowe L, Murray CS, Custovic A, Simpsom BM, Kissen PM, Woodcock A. Specific airway resistance in 3-year-old children: a prospective cohort study. Lancet. 2002;359:1904–1908
  24. Freidhoff LR, Marsh DG. Relationship among asthma, serum IgE and skin test reactivity to inhaled allergens. Int Arch Allergy Immunol. 1993;100:355–361
  25. Sears MR, Burrows B, Flawndry EM, Herbison GP, Hewitt CJ, Holdaway MD. Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children. N Engl J Med. 1991;325:1067–1071
  26. Burrows B, Martinez FD, Halonen M, Barbee RA, Cline G. Association of asthma with serum IgE levels and skin test reactivity to allergens. N Engl J Med. 1989;320:271–277
  27. Peat JK, Salome CM, Woolcock AJ. Longitudinal changes in atopy during a 4-year period, relation to bronchial hyperresponsiveness and respiratory symptoms in a population sample of Australian school children. J Allergy Clin Immunol. 1990;85:65–74
  28. Sherrill DL, Stein RT, Halonen M, Holberg CJ, Wright A, Martinez FD. Total serum IgE and its association with asthma symptoms and allergic sensitization among children. J Allergy Clin Immunol. 1999;104:28–36
  29. Illi S, von Mutius E, Lau S, et al.  The pattern of atopic sensitization is associated with the development of asthma in childhood. J Allergy Clin Immunol. 2001;108:709–714

PII: S1526-0542(04)00021-1

doi: 10.1016/j.prrv.2004.01.007

Paediatric Respiratory Reviews
Volume 5, Issue 2 , Pages 155-161 , June 2004

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