Paediatric Respiratory Reviews
Volume 5, Issue 1 , Pages 40-44 , March 2004

Brittle asthma

  • Jon G Ayres

      Affiliations

    • Department of Environmental and Occupational Medicine, University of Aberdeen, Foresterhill Road, Aberdeen AB25 2ZP, UK
    • ,
  • Deepti Jyothish

      Affiliations

    • West Midlands Deanery, Birmingham, UK
    • ,
  • Titus Ninan

      Affiliations

    • Department of Paediatrics, Heartlands and Solihull NHS Trust, Bordesley Green East, Birmingham B9 5SS, UK
    • Corresponding Author InformationCorrespondence to: T. K. Ninan. Tel.: +44 121 424 2819

References 

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  3. Mitchell EA, Anderson HR, Freeling P, White PT. Why are hospital admission and mortality rates for childhood asthma higher in New Zealand than in the United Kingdom?. Thorax. 1990;45:176–182
  4. Ng TP, Tan WC. Temporal trends and ethnic variations in asthma mortality in Singapore, 1976–1995. Thorax. 1999;54:990–994
  5. Ayres JG. Severe asthma phenotypes–a case for more specificity. J. Roy Soc. Med. 2001;94:115–118
  6. Turner-Warwick M. On observing patterns of airflow asthma. Br. J. Dis. Chest. 1977;71:73–86
  7. Ayres JG, Miles JF, Barnes PJ. Brittle asthma. Thorax. 1998;53:315–321
  8. ten Brinke A, Zwinderman AH, Sterk PJ, Rabe KF, Bel EH. Factors associated with persistent airflow limitation in severe asthma. Am. J. Respir. Crit. Care Med. 2001;164:744–748
  9. Dragos D, Campbell D, Robinson DS, Chung KF. Significance of persistent airflow obstruction in patients with severe asthma. Eur. Respir. J. 2002;20:406s
  10. Ayres JG, Chung KF, Szczepura A, et al.  Patients with at risk asthma have a high frequency of reported asthma death in first degree relatives–evidence from the PARA UK database. Thorax. 2001;56:S103
  11. Penfold R, Davies N, Ayres J. Beta-2 receptor polymorphisms in severe and brittle asthma. Thorax. 2001;56:P12
  12. Hall IP, Wheatley A, Wilding P, Liggett SB. Association of the Glu 27 beta 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects. Lancet. 1995;345:1213–1214
  13. Miles JF, Cayton RM, Tunnicliffe WS, Ayres JG. Increased atopic sensitization in brittle asthma. Clin. Exp. Allergy. 1995;25:1074–1082
  14. Tunnicliffe WS, Fletcher TJ, Hammond K, et al.  Sensitivity and exposure to indoor allergens in adults with differing asthma severity. Eur. Resp. J. 1999;13:654–659
  15. Garden GMF, Ayres JG. Psychiatric and social aspects of brittle asthma. Thorax. 1993;48:501–505
  16. Miles JF, Garden G, Ayres JG. Psychological factors in brittle asthma: a case control study. Clin. Exp. Allergy. 1997;27:1151–1159
  17. Baker C, Tunnicliffe WS, Duncanson R, Ayres JG. Double blind placebo controlled studies of food intolerance in brittle asthma. J. Am. Dietet. Assoc. 2000;100:1361–1367
  18. Baker JC, Ayres JG. Food allergy and asthma. In: Brostoff J, Challacombe S (eds) Food Allergy, 2nd edn. London: WB Saunders, 2002.
  19. Baker JS, Tunnicliffe WS, Duncanson RC, Ayres JG. Dietary antioxidants and magnesium in type 1 brittle asthma: a case control study. Thorax. 1999;54:115–118
  20. Ayres JG, Thompson RA. IgG sub-class deficiency in brittle asthma and in patients with recurrent infective exacerbations of asthma. Respir. Med. 1997;91:464–469
  21. Douwes J, Gibson P, Pekkanen J, Pearce N. Non-eosinophilic asthma: importance and possible mechanisms. Thorax. 2002;57:643–648
  22. Kaur B, Anderson HR, Austin J, et al.  Prevalence of asthma symptoms, diagnosis, and treatments in 12–14 year old children across Great Britain (International Study of Asthma and Allergies in Childhood, ISAAC UK). Br. Med. J. 1998;316:118–124
  23. Payne DN, Wilson NM, James A, et al.  Evidence for different subgroups of difficult asthma in children. Thorax. 2001;56:345–350
  24. Myers TR. Pediatric asthma epidemiology: incidence, morbidity, and mortality. Respir. Care Clin. N. America. 2000;1:1–14
  25. Sly RM, O’Donnell R. Stabilization of asthma mortality. Ann. Allergy, Asthma Immunol. 1997;78:347–354
  26. O’Driscoll BRC, Ruffles SP, Ayres JG, Cochrane GM. Long term treatment of severe asthma with subcutaneous terbutaline. Brit. J. Dis. Chest. 1988;82:360–367
  27. Ayres JG, Fish DR, Wheeler DC, et al.  Subcutaneous terbutaline and control of brittle asthma or appreciable morning dipping. Br. Med. J. 1984;288:1715–1716
  28. Payne DN, Balfour-Lynn IM, Biggart EA, Bush A, Rosenthal M. Subcutaneous terbutaline in children with chronic severe asthma. Pediatr. Pulmonol. 2002;33:356–361
  29. Everill JE, Gupta D, Anees W, Baker JC, Ayres JG. Audit of long term central venous access devices in patients with Type 1 brittle asthma. Asthma J. 2001;6:20–26
  30. Ninan TK, Russell G. Asthma, inhaled corticosteroid treatment, and growth. Arch Dis. Child. 1992;67:703–705

PII: S1526-0542(03)00100-3

doi: 10.1016/j.prrv.2003.09.003

Paediatric Respiratory Reviews
Volume 5, Issue 1 , Pages 40-44 , March 2004

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